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STRATEGY
&
TECHNOLOGY
KINARIS combines protein structure
determination and target-based rational drug
design with chemical synthesis to generate a new
class of therapeutic drugs for the treatment of
various myosin-associated diseases.
KINARIS
has initially focused the drug development
process on the generation of specific inhibitors
against parasitic myosins. This is being
realized through the establishment of an interdisciplinary infrastructure
embracing three closely interacting departments:
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Cell
Technology & Pharmacology (CTP)
(more...)
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Enzymology,
Molecular Structure & Design (EMSD)
EMSD is responsible for a diverse set of
activities concerning discovery and
characterization of small molecule-protein and
protein-protein interactions. EMSD selects and
produces protein targets for use in high
throughput screening, utilizing expression
systems and natural sources. The department
assays candidate compounds and determines the
compounds mechanism of action. A variety of
techniques such as enzyme and transient
kinetics, fluorescence spectroscopy, protein
crystallography, and molecular modeling are
employed to gain detailed insights into
protein-compound interactions and to aid
compound prioritization.
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